HCID 131718675, compound → HCID 131718674, compound

HRID 2226377Notes

Reaction equation

HRID 2226377 reaction equation
[C:1]([C:5]1[N:10]2[C:11](=[S:15])[C@H:12]([O:13][CH3:14])[C@H:9]2[S:8](=[O:17])(=[O:16])[CH:7]([CH2:18][C:19]([O:21]C(C2C=CC=CC=2)C2C=CC=CC=2)=[O:20])[C:6]=1[CH3:35])([CH3:4])([CH3:3])[CH3:2]>ClCCl.C1(OC)C=CC=CC=1.FC(F)(F)C(O)=O>[C:1]([C:5]1[N:10]2[C:11](=[S:15])[C@H:12]([O:13][CH3:14])[C@H:9]2[S:8](=[O:16])(=[O:17])[CH:7]([CH2:18][C:19]([OH:21])=[O:20])[C:6]=1[CH3:35])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 1

HCID 131718675HCID 131718675, compound

Product 1

HCID 131718674HCID 131718674, compound

Reagents, catalysts & solvents 3

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolventHCID 7519AnisoleSolvent

Procedure

To a solution of 4-tert-butyl-7α-methoxy-3-methyl-2-(benzhydryloxycarbonylmethyl)thio-3-cephem 1,1-dioxide (see Example 16) (20 mg) in dichloromethane (0.5 ml), anisole (60 ml) and trifluoroacetic acid (0.3 ml) were added sequentially. The mixture was let stand for 3 hours at room temperature then concentrated in vacuo. Diisopropylether (10 ml) was added under stirring. The light yellow powder thus obtained was filtered and dried in vacuo (12 mg).

Workup

  1. customfor 3 hours
  2. customat room temperature
  3. concentrationthen concentrated in vacuo
  4. additionDiisopropylether (10 ml) was added
  5. customThe light yellow powder thus obtained
  6. filtrationwas filtered
  7. customdried in vacuo (12 mg)

Sources & evidence

ORD record
ord-d2e925a8ee884e59a795e01f0593c7f0
Source dataset
uspto-grants-1994_09
Patent number
US05348952

Reaction notes

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