1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(2,5-dioxo-1-pyrrolidinyl) ester, (2S)- → HCID 178451949, compound

HRID 2226733Notes

Reaction equation

HRID 2226733 reaction equation
[NH:1]([C:20]([O:22]C(C)(C)C)=O)[C@H:2]([C:13]([NH:15][CH2:16][C:17]([NH2:19])=[O:18])=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10].Cl.CCOC(C)=O.[N:34]1([C:49]([O:51][C:52]([CH3:55])([CH3:54])[CH3:53])=[O:50])[CH2:48][CH2:47][CH2:46][C@H:35]1C(ON1C(=O)CCC1=O)=O>CCN(CC)CC>[N:34]1([C:49]([O:51][C:52]([CH3:55])([CH3:54])[CH3:53])=[O:50])[CH2:48][CH2:47][CH2:46][C@H:35]1[C:20]([NH:1][C@H:2]([C:13]([NH:15][CH2:16][C:17]([NH2:19])=[O:18])=[O:14])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:12])[NH:8][N+:9]([O-:11])=[O:10])=[O:22]

Participants

5

Reactant 3

HCID 8538831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) 2-(2,5-dioxo-1-pyrrolidinyl) ester, (2S)-HCID 21866389Hydrogen chloride-ethyl acetateHCID 178454199Boc-Arg(NO2)-Gly-NH2

Product 1

HCID 178451949HCID 178451949, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The desired compound was prepared from 6.0 g of Boc-Arg(NO2)-Gly-NH2, 40 ml of 4 N HCl-AcOEt, 3.4 ml of Et3N and 5.1 g of Boc-Pro-OSu in the same manner as in Example 26-(4).

Sources & evidence

ORD record
ord-73b6f4aab7f74b0cba0d1a0bc1480753
Source dataset
uspto-grants-1994_09
Patent number
US05349050

Reaction notes

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