Sodium Carbonate → Enalapril

HRID 2226803Notes

Reaction equation

HRID 2226803 reaction equation
[Na].C(=O)([O-])[O-].[Na+].[Na+].C(=O)([O-])O.[Na+].[OH-].[Na+].[CH3:15][CH2:16][O:17][C:18]([C@@H:20]([NH:29][C@H:30]([C:32]([N:34]1[C@H:38]([C:39]([O-:41])=[O:40])[CH2:37][CH2:36][CH2:35]1)=[O:33])[CH3:31])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19].[Na+]>O>[CH3:15][CH2:16][O:17][C:18]([C@@H:20]([NH:29][C@H:30]([C:32]([N:34]1[C@H:38]([C:39]([OH:41])=[O:40])[CH2:37][CH2:36][CH2:35]1)=[O:33])[CH3:31])[CH2:21][CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)=[O:19]

Participants

7

Reactant 5

HCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 5360545SodiumHCID 23673231Enalapril sodium

Product 1

HCID 5388962Enalapril

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The stable formulation of enalapril salt is prepared in such manner that a compound of formula II ##STR5## is suspended in demineralized water, a stoichiometric amount of the corresponding sodium compound such as sodium carbonate, sodium hydrogen carbonate or sodium hydroxide is added thereto, to this enalapril sodium salt prepared in situ of the formula I ##STR6## formulating additives are added, the whole is homogenized and formulated.

Workup

  1. additionare added

Sources & evidence

ORD record
ord-8b29d864f1e14959b0a631689bc47424
Source dataset
uspto-grants-1994_09
Patent number
US05350582

Reaction notes

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