HCID 18963816, compound → HCID 18963819, compound

HRID 2226839Notes

Reaction equation

HRID 2226839 reaction equation
C1(C2[O:12][CH2:11][CH:10]([O:13][C:14]([C:16]3[N:17]=[CH:18][C:19]4[NH:20][C:21]5[C:26]([C:27]=4[C:28]=3[CH2:29][O:30][CH3:31])=[CH:25][C:24]([O:32][CH2:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[CH:23][CH:22]=5)=[O:15])[CH2:9][O:8]2)C=CC=CC=1>Cl>[OH:8][CH2:9][CH:10]([O:13][C:14]([C:16]1[N:17]=[CH:18][C:19]2[NH:20][C:21]3[C:26]([C:27]=2[C:28]=1[CH2:29][O:30][CH3:31])=[CH:25][C:24]([O:32][CH2:33][C:34]1[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=1)=[CH:23][CH:22]=3)=[O:15])[CH2:11][OH:12]

Participants

3

Reactant 1

HCID 18963816HCID 18963816, compound

Product 1

HCID 18963819HCID 18963819, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

135 mg of 6-benzyloxy-4-methoxymethyl-β-carboline-3carboxylic acid-(2-phenyl-1,3-dioxan-5-yl)-ester under 10 ml of acetone and 100 ml of 4N hydrochloric acid is stirred for 1 hour at 80° C. bath temperature. The batch is concentrated by evaporation, taken up in aqueous ammonia and suctioned off. 100 mg of 6-benzyloxy-4-methoxymethyl-β-carboline-3-carboxylic acid-(1,3-dihydroxy-propan-2-yl)-ester of a melting point of 190°-192° C. is obtained.

Workup

  1. concentrationThe batch is concentrated by evaporation

Sources & evidence

ORD record
ord-ab1a5cad7c9f462db9c0e3ef74cd285c
Source dataset
uspto-grants-1994_09
Patent number
US05350750

Reaction notes

Loading…