Formic Acid → 3-(3,4-Dimethoxyphenyl)propionic acid

HRID 2227015Notes

Reaction equation

HRID 2227015 reaction equation
CC1(C)[O:9][C:7](=[O:8])[CH2:6][C:4](=O)O1.C(=O)[C:12]1[CH:21]=[CH:20][C:17]([O:18][CH3:19])=[C:14]([O:15][CH3:16])[CH:13]=1.C(O)=O>C(N(CC)CC)C>[CH3:16][O:15][C:14]1[CH:13]=[C:12]([CH2:4][CH2:6][C:7]([OH:9])=[O:8])[CH:21]=[CH:20][C:17]=1[O:18][CH3:19]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 8419VeratraldehydeHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 750193-(3,4-Dimethoxyphenyl)propionic acid

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

7.2 g (0.05 mol) of Meldrum's acid and 8.3 g (0.05 mol) of veratraldehyde were weighed to 40 ml of the mixture of formic acid and triethylamine recovered by distillation in Example 3. The reaction was carried out and the final product was separated as described in Example 3. The volume of the mixture of formic acid and triethylamine recovered amounted to 28 ml.

Workup

  1. distillationrecovered by distillation in Example 3
  2. customthe final product was separated
  3. additionThe volume of the mixture of formic acid and triethylamine
  4. customrecovered

Sources & evidence

ORD record
ord-91963f216fd142f3ab31700f33348d98
Source dataset
uspto-grants-1994_09
Patent number
US05350872

Reaction notes

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