反应详情

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

1. temperatureat reflux overnight
2. extractionThe acid product is extracted with ethyl acetate
3. washthe combined organic layers are washed with brine
4. dry with materialdried over magnesium sulfate
5. concentrationThe solution is concentrated in vacuo