反应详情

To a round-bottom flask equipped with a stirbar is added phenol 2G (R=4-Methyl-3-pentenyl) (5 g), tosylate 1H (R=n-pentyl) (5.95 g), cesium carbonate (7.45 g), and anhydrous dimethylforrnamide (50 mL). The reaction mixture is stirred overnight. It is then poured into 50 mL dilute HCl, and extracted with 1:1 hexanes:ethyl acetate. The combined organic layers are washed with brine and dried over potassium carbonate, and the solution is concentrated in vacuo. Filtration through silica gel using 10% ethyl acetate in hexanes gives the pure product.

1. customTo a round-bottom flask equipped with a stirbar
2. extractionextracted with 1:1 hexanes
3. washThe combined organic layers are washed with brine
4. dry with materialdried over potassium carbonate
5. concentrationthe solution is concentrated in vacuo
6. filtrationFiltration through silica gel using 10% ethyl acetate in hexanes
7. customgives the pure product