反应详情

A mixture of 6-phenyl-3(2H)-pyridazinone potassium salt (10 mmol) (prepared from 6-phenyl-3(2H)-pyridazinone (1.72 g; 10 mmol) and KOH in methanol (0.56 g; 10 mmol), 2-bromoethanol (12 mmol), TBAB (1.19 g; 4 mmol) and atomised KOH (11 mmol) in toluene (60 mL) was stirred at room temperature for 6 hours. The reaction mixture was filtered, the filtrate was washed successively with 5% NaOH solution, 10% HCl solution and lastly water. The organic extracts were dried over anhydrous Na2SO4 and concentrated to dryness, and the obtained residue was purified by flash chromatography (CH22Cl2MeOH 98:2), yielding the title product (1.9 g).

1. filtrationThe reaction mixture was filtered
2. washthe filtrate was washed successively with 5% NaOH solution, 10% HCl solution and lastly water
3. dry with materialThe organic extracts were dried over anhydrous Na2SO4
4. concentrationconcentrated to dryness
5. customthe obtained residue was purified by flash chromatography (CH22Cl2MeOH 98:2)