Triethylamine → HCID 178478732, compound

HRID 2227288Notes

Reaction equation

HRID 2227288 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:4](Cl)[N:3]=1.[ClH:17].[I:18][C:19]1[CH:20]=[C:21]([CH:24]=[CH:25][CH:26]=1)[CH2:22][NH2:23].C([N:29]([CH2:32][CH3:33])CC)C>C(O)C>[ClH:1].[ClH:17].[NH2:8][C@H:11]1[CH2:15][CH2:33][C@H:32]([NH:29][C:2]2[N:10]=[C:9]3[C:5]([N:6]=[CH:7][N:8]3[CH:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)=[C:4]([NH:23][CH2:22][C:21]3[CH:24]=[CH:25][CH:26]=[C:19]([I:18])[CH:20]=3)[N:3]=2)[CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 27238613-Iodobenzylamine hydrochlorideHCID 108011162,6-dichloro-9-cyclopentyl-9H-purine

Product 1

HCID 178478732HCID 178478732, compoundYield 93.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Dissolve 2,6-dichloro-9-cyclopentylpurine (620 mg, crude), 3-iodobenzylamine hydrochloride (810 mg, 3.00 mmol) and triethylamine (835 μL, 6.00 mmol) in dry ethanol (20 mL). Heat at reflux for 15 hours, cool, and filter the solid to give the title compound as a white solid (680 mg).

Workup

  1. temperatureHeat
  2. temperatureat reflux for 15 hours
  3. temperaturecool
  4. filtrationfilter the solid

Sources & evidence

ORD record
ord-eaa48226350e4cfc8519326fc290f9a6
Source dataset
uspto-grants-2002_07
Patent number
US06413974B1

Reaction notes

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