Cyclopentanol → 2,6-dichloro-9-(propan-2-yl)-9H-purine

HRID 2227302Notes

Reaction equation

HRID 2227302 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([Cl:11])[N:3]=1.[CH:12]1(O)[CH2:16]CC[CH2:13]1>C(O)(C)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:12]([CH3:16])[CH3:13])=[C:4]([Cl:11])[N:3]=1

Participants

4

Reactant 2

HCID 7298CyclopentanolHCID 53244122,6-Dichloropurine

Product 1

HCID 112184902,6-dichloro-9-(propan-2-yl)-9H-purine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2,6-Dichloro-9-(2-propyl)purine is prepared from 2,6-dichloropurine and isopropanol essentially as described in Example 1, Scheme A, step a, but substituting isopropanol for cyclopentanol.

Sources & evidence

ORD record
ord-98889609b8b84dd690a0a0b11b68af02
Source dataset
uspto-grants-2002_07
Patent number
US06413974B1

Reaction notes

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