Cyclopropanemethanamine → 2-Chloro-6-[(cyclopropyl)methylamino]-9-(2-propyl)purine

HRID 2227318Notes

Reaction equation

HRID 2227318 reaction equation
[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4](Cl)[N:3]=1.[CH:15]1([CH2:18][NH2:19])[CH2:17][CH2:16]1>C(N(CC)CC)C>[Cl:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH:11]([CH3:13])[CH3:12])=[C:4]([NH:19][CH2:18][CH:15]2[CH2:17][CH2:16]2)[N:3]=1

Participants

4

Reactant 2

HCID 75646CyclopropanemethanamineHCID 112184902,6-dichloro-9-(propan-2-yl)-9H-purine

Product 1

HCID 867583002-Chloro-6-[(cyclopropyl)methylamino]-9-(2-propyl)purine

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

2-Chloro-6-[(cyclopropyl)methylamino]-9-(2-propyl)purine is prepared from 2,6-dichloro-9-(2-propyl)purine (See Example 15 for preparation), cyclopropylmethylamine, and triethylamine essentially as described above in Example 1, Scheme A, step b.

Sources & evidence

ORD record
ord-02e6745b8d3848879f7cde803d1183b8
Source dataset
uspto-grants-2002_07
Patent number
US06413974B1

Reaction notes

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