Hydrochloric Acid → HCID 178469836, compound

HRID 2227370Notes

Reaction equation

HRID 2227370 reaction equation
C(=O)(O)O.[NH2:5][C:6]([NH2:8])=[NH:7].[CH2:9]([O:11][C:12](=[O:23])[C:13](=[CH:19]OCC)[C:14](OCC)=[O:15])[CH3:10].O.Cl>C(O)C>[CH2:9]([O:11][C:12]([C:13]1[C:14]([OH:15])=[N:7][C:6]([NH2:8])=[N:5][CH:19]=1)=[O:23])[CH3:10]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6871Diethyl (ethoxymethylene)malonateHCID 286947Carbonic acid-guanidine (1:1)

Product 1

HCID 178469836HCID 178469836, compoundYield 83.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Guanidine carbonate (18.0 g, 200 mmol) is dissolved in ethanol (300 ml), and then sodium alcoholate (13.6 g) and ethoxymethylenemalonic acid diethyl ester (43.2 g, 200 mmol) are added at room temperature. After stirring at room temperature for 4 days, the mixture is concentrated to dryness under reduced pressure. To the residue obtained, water (500 ml) is added and neutralized with hydrochloric acid, and then the crystal precipitated is collected by filtration and recrystallized, to yield a white crystal (30.5 g, 83%).

Workup

  1. concentrationthe mixture is concentrated to dryness under reduced pressure
  2. customTo the residue obtained
  3. customthe crystal precipitated
  4. filtrationis collected by filtration
  5. customrecrystallized

Sources & evidence

ORD record
ord-2f09950906834eb3828a1ff685dbc0ec
Source dataset
uspto-grants-2002_07
Patent number
US06413972B1

Reaction notes

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