Butyl iodide → HCID 18473723, compound

HRID 2227438Notes

Reaction equation

HRID 2227438 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][OH:9].[CH2:10](I)[CH2:11][CH2:12][CH3:13].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH2:10]([N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][OH:9])[CH2:11][CH2:12][CH3:13]

Participants

5

Reactant 3

HCID 10962Butyl iodideHCID 11430Potassium CarbonateHCID 151442-Piperidin-2-ylethanol

Product 1

HCID 18473723HCID 18473723, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2-Piperidineethanol (15 g, 0.12 mol), n-butyl iodide (23.5 g, 0.13 mol) and potassium carbonate (32.1 g, 0.23 mol) in actonitrile (250 ml), as described in example 3 above, gave 1-butyl-2-piperidineethanol (16.2 g, 75%).

Sources & evidence

ORD record
ord-76536052127246d68dee939819efaadd
Source dataset
uspto-grants-2002_07
Patent number
US06413987B1

Reaction notes

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