反应详情

温度

80 °C

A suspension of 4-formylcinnamic acid (1.76 g), p-methoxybenzyl chloride (1.63 ml) and potassium carbonate (2.76 g) in 20 ml dimethylformamide was stirred at 80° C. for 7 hours, and then allowed to cool. The reaction mixture was extracted with ethyl acetate and washed with water. The combined organic layers were dried over magnesium sulfate. The drying agent was filtered off and the filtrate was evaporated under reduced pressure and dried to give p-anisyl 4formylcinnamate of interest (2.96 g, 100%) as a pale yellow solid.

1. temperatureto cool
2. extractionThe reaction mixture was extracted with ethyl acetate
3. washwashed with water
4. dry with materialThe combined organic layers were dried over magnesium sulfate
5. filtrationThe drying agent was filtered off
6. customthe filtrate was evaporated under reduced pressure
7. customdried