Hydrochloric Acid → HCID 9956698, compound

HRID 2227568Notes

Reaction equation

HRID 2227568 reaction equation
[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:32][CH3:33])=[C:9]([CH:31]=1)[C:10]([NH:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:29][CH3:30])=[C:19]([S:21]([NH:24][C:25]([NH:27][CH3:28])=S)(=[O:23])=[O:22])[CH:20]=1)=[O:11])([CH3:4])([CH3:3])[CH3:2].[OH:34]O.Cl>[OH-].[Na+]>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([O:32][CH3:33])=[C:9]([CH:31]=1)[C:10]([NH:12][CH2:13][CH2:14][C:15]1[CH:16]=[CH:17][C:18]([O:29][CH3:30])=[C:19]([S:21]([NH:24][C:25]([NH:27][CH3:28])=[O:34])(=[O:22])=[O:23])[CH:20]=1)=[O:11])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 9913632260971-17-3

Product 1

HCID 9956698HCID 9956698, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

0.252 g (0.5 mmol) of 1-[[5-[2-(5-tert-butyl-2-methoxybenzamido)ethyl]-2-methoxyphenyl]sulfonyl]-3-methylthiourea (Example 1) were dissolved in 2.5 ml of 2 N aqueous sodium hydroxide solution and admixed with ice-cooling with 0.25 ml of 30% strength hydrogen peroxide. The solution was stirred at room temperature for 24 h and poured into a mixture of ice-water and 2 N hydrochloric acid. Drying in the air gave white crystals of melting point 209-212° C.

Workup

  1. customDrying in the air
  2. customgave white crystals of melting point 209-212° C.

Sources & evidence

ORD record
ord-26b6e194295f428c83afb2a692d6ec30
Source dataset
uspto-grants-2002_07
Patent number
US06414030B1

Reaction notes

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