Lithium Hydroxide → HCID 69263394, compound

HRID 2227740Notes

Reaction equation

HRID 2227740 reaction equation
[CH2:1]1[CH:12]2[CH:4]([NH:5][C:6]3[C:7]([C:13]([NH:15][C@H:16]([CH3:21])[C:17]([O:19]C)=[O:18])=[O:14])=[CH:8][CH:9]=[CH:10][C:11]=32)[CH2:3][CH2:2]1.[OH-].[Li+]>C1COCC1>[CH2:1]1[CH:12]2[CH:4]([NH:5][C:6]3[C:7]([C:13]([NH:15][C@H:16]([CH3:21])[C:17]([OH:19])=[O:18])=[O:14])=[CH:8][CH:9]=[CH:10][C:11]=32)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 86617447HCID 86617447, compound

Product 1

HCID 69263394HCID 69263394, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the procedure of method 1D, methyl (2R)-2-[(1,2,3,3a,4,8b-hexahydrocyclopenta[b]indol-5-ylcarbonyl)amino]propanoate (2.7 mmol, 0.77 g) was hydrolyzed to the acid using 1 M aqueous lithium hydroxide (5.9 mL) in THF (20 mL) to yield an orange oil which was used without further purification.

Workup

  1. customto yield an orange oil which
  2. customwas used without further purification

Sources & evidence

ORD record
ord-db828ef5f166417493bd1d35e557b0ac
Source dataset
uspto-grants-2002_07
Patent number
US06414144B1

Reaction notes

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