Potassium Iodide → HCID 22087132, compound

HRID 2227782Notes

Reaction equation

HRID 2227782 reaction equation
[OH:1][C@@H:2]([CH2:18][N:19]([C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=1)[CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:3][O:4][C:5]1[C:17]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1.C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>C(C(CC)=O)C>[OH:1][C@@H:2]([CH2:18][N:19]([C:24]1[CH:29]=[CH:28][C:27]([O:30][CH2:15][CH2:16][CH:17]([C:9]#[N:10])[CH2:5][CH3:6])=[CH:26][CH:25]=1)[CH2:20][CH:21]([CH3:23])[CH3:22])[CH2:3][O:4][C:5]1[C:17]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 54420518HCID 54420518, compound

Product 1

HCID 22087132HCID 22087132, compoundYield 145.6%

Reagents, catalysts & solvents 1

HCID 7288Ethyl ketoneSolvent

Procedure

A mixture of the phenol prepared in example 91 (0.90 g, 2.2 mmol), 4-bromocaproonitrile (0.6 mL, 5.0 mmol), potassium carbonate (0.97 g, 7.0 mmol), potassium iodide (0.1 g) and ethyl ethyl ketone (30 mL) was heated at reflux for 10 h. The reaction was concentrated in vacuo and the resulting residue partitioned between EtOAc and water. The layers were separated and the aqueous layer extracted with EtOAc (3x). The combined organic layers were washed with water (3x), brine, dried (MgSO4), and concentrated in vacuo to a light pink oil, The material was purified by flash chromatography over silica gel eluting with 5% MeOH/CHCl3 to provide 0.80 g (72%) of a clear oil. MS (FD+) 500.78 (MH+). NMR.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 10 h
  3. concentrationThe reaction was concentrated in vacuo
  4. customthe resulting residue partitioned between EtOAc and water
  5. customThe layers were separated
  6. extractionthe aqueous layer extracted with EtOAc (3x)
  7. washThe combined organic layers were washed with water (3x), brine
  8. dry with materialdried (MgSO4)
  9. concentrationconcentrated in vacuo to a light pink oil
  10. customThe material was purified by flash chromatography over silica gel eluting with 5% MeOH/CHCl3

Sources & evidence

ORD record
ord-2142a07f46dc4a80bcb1cc86e1c8c3f6
Source dataset
uspto-grants-2002_07
Patent number
US06413991B1

Reaction notes

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