反应详情

2.9 g (10 mmol) of chloroethylpiperazine and 2.8 g (20 mmol) of potassium carbonate were added to a solution of 2.4 g (10 mmol) of tetrahydropyridopyrimidine in 40 ml of DMF. After reaction at 90° C. for two hours, and then poured onto ice-water and extracted with ethyl acetate. The organic phase was washed with saturated sodium chloride solution and dried over sodium sulfate, and the solvent was removed under reduced pressure. The oil that remained was taken up in acetone, and the hydrochloride was precipitated out using isopropanol/HCI. This gave 4 g (75%) of the product were obtained (melting point 205° C.).

1. customAfter reaction at 90° C. for two hours
2. additionpoured onto ice-water
3. extractionextracted with ethyl acetate
4. washThe organic phase was washed with saturated sodium chloride solution
5. dry with materialdried over sodium sulfate
6. customthe solvent was removed under reduced pressure
7. customthe hydrochloride was precipitated out