反应详情

In DMF (3 ml) was dissolved N-[4—(chloromethyl)- phenyl]-7-phenyl-3,4-dihydronaphthalene-2-carboxamide (140 mg), and to the mixture was added 1-ethylpiperidine (154 μl). The mixture was stirred at room temperature for 14 hours and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate-methanol to give 1-ethyl-1-[4—(7-phenyl-3,4-dihydro-naphthalene-2-carboxamido)benzyl]piperidinium chloride (Compound 24) (125 mg) as colorless crystals.

1. concentrationconcentrated under reduced pressure
2. customThe residue was recrystallized from ethyl acetate-methanol