反应详情

In DMF (3 ml) was dissolved N-[4—(4-benzyl-piperidino-methyl)phenyl]-7—(4-methylphenyl)-3,4-dihydronaphthalene-2-carboxamide (150 mg), and to the mixture was added methyliodide (53 μl). The mixture was stirred at room temperature for 23 hours. To the reaction mixture was added ethyl acetate(100 ml), and the resulting precipitate was filtered to give 4-benzyl-1-methyl-1-[4-[7—(4-methylphenyl)-3,4-dihydronaphthalene-2-carboxamido]benzyl]-piperidinium iodide (Compound 36) (141 mg, ratio of isomers=19:81) as colorless crystals.

1. filtrationthe resulting precipitate was filtered