HCID 86757228, compound → HCID 18472387, compound

HRID 2228294Notes

Reaction equation

HRID 2228294 reaction equation
CO[CH:3]1[C:17](=C=O)[C:16]([N+:20]([O-])=O)=[CH:15][CH:14]=[C:4]1[O:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]>C1COCC1.[C].[Pd]>[NH2:20][C:16]1[CH:15]=[CH:14][C:4]([O:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:3]([C:9]([O:11][CH3:12])=[O:10])[CH:17]=1

Participants

4

Reactant 1

HCID 86757228HCID 86757228, compound

Product 1

HCID 18472387HCID 18472387, compoundYield 205.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

In THF (25 ml) was dissolved ethyl 4-(2-methoxy-carbonyl-4-nitrophenoxy)butyrate (2.37 g, 7.61 mmol), and to the mixture was added 10% palladium-carbon (containing 50% water, 0.94 g). The mixture was subjected to catalytic reduction at room temperature for 4 hours. Insoluble materials were filtered off, and the filtrate was dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give ethyl 4-(4-amino-2-methoxycarbonylphenoxy)butyrate (2.20 g). IR (KBr): 1730 cm−1.

Workup

  1. filtrationInsoluble materials were filtered off
  2. dry with materialthe filtrate was dried with anhydrous magnesium sulfate
  3. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-a7389b23bfa44972a9ab9f4358107a1a
Source dataset
uspto-grants-2002_07
Patent number
US06413947B1

Reaction notes

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