反应详情

温度

100 °C

Next, to a flask of 200 ml capacity fitted with a stirrer and cooling tube, there were introduced 15.4 g of 1-(2-chloroethyl)indole, 21.3 g of potassium methacrylate, 7.1 g of potassium iodide, 40 ml of N,N-dimethyl formamide and a small amount of hydroquinone. The mixture was heated to 100° C. and was stirred for 2.5 hours. After completion of the reaction, the insoluble material was removed by filtration, and concentration was performed under reduced pressure. This reaction mixture was then purified by column chromatography using silica gel, to obtain 15.5 g of 1-(2-methacryloyloxyethyl)indole.

1. customNext, to a flask of 200 ml capacity fitted with a stirrer
2. temperaturecooling tube
3. customAfter completion of the reaction
4. customthe insoluble material was removed by filtration, and concentration
5. customThis reaction mixture was then purified by column chromatography