反应详情

温度

100 °C

To 1 g of 2-piperidinoaniline in 10 mL of DMF are added 1.72 mL of 4-methoxyphenethyl chloride (2 equivalents) and 2.35 g of potassium carbonate (3 equivalents). The whole is heated to 100° C. for 60 hrs and then poured on ice and extracted with ethyl acetate. The organic phase washed with a saturated solution of sodium chloride is dried on magnesium sulfate, filtered and evaporated under reduced pressure. With several silica gel chromatographies of the residue (petroleum ether, petroleum ether/ethyl acetate: 98/2), 255 mg of the desired product were able to be isolated.

1. additionpoured on ice
2. extractionextracted with ethyl acetate
3. washThe organic phase washed with a saturated solution of sodium chloride
4. customis dried on magnesium sulfate
5. filtrationfiltered
6. customevaporated under reduced pressure
7. customto be isolated