Water → HCID 21685517, compound

HRID 2228955Notes

Reaction equation

HRID 2228955 reaction equation
[CH:1]([NH2:14])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:15](N1C=CN=C1)([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)=[O:16].O>ClCCl>[CH:1]([NH:14][C:15]([N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1)=[O:16])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7036BenzhydrylamineHCID 682631,1'-Carbonyldiimidazole

Product 1

HCID 21685517HCID 21685517, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

Benzhydrylamine (1.83 g) was dissolved in dichloromethane (3.0 ml). Carbonyldiimidazole (1.78 g) was added to the solution. The mixture was stirred at room temperature overnight. Water and dichloromethane were added thereto. The mixture was stirred, and then extracted with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate. The solvent was then removed by distillation to give imidazole-1-carboxylic acid benzhydrylamide.

Workup

  1. stirringThe mixture was stirred
  2. extractionextracted with dichloromethane
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. customThe solvent was then removed by distillation

Sources & evidence

ORD record
ord-21520e7e4af04387a3f287e4e677ee5c
Source dataset
uspto-grants-2002_07
Patent number
US06417362B1

Reaction notes

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