Acetonitrile → HCID 18466529, compound

HRID 2229118Notes

Reaction equation

HRID 2229118 reaction equation
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:19]=[CH:18][C:6]([C:7]([C:9]2[C:10]([CH3:17])=[N:11][N:12]([CH2:15][CH3:16])[C:13]=2[OH:14])=[O:8])=[C:5]([S:20]([CH3:23])(=[O:22])=[O:21])[CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:32][C:33]#N>O>[S:20]([C:32]1[CH:33]=[CH:2][C:3]([CH3:19])=[CH:4][CH:5]=1)([O:14][C:13]1[N:12]([CH2:15][CH3:16])[N:11]=[C:10]([CH3:17])[C:9]=1[C:7](=[O:8])[C:6]1[CH:18]=[CH:19][C:3]([C:2]([F:24])([F:1])[F:25])=[CH:4][C:5]=1[S:20]([CH3:23])(=[O:22])=[O:21])(=[O:22])=[O:21]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 178463091HCID 178463091, compound

Product 1

HCID 18466529HCID 18466529, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

0.37 g (1 mmol) of 4-(4-Trifluoromethyl-2-methylsulfonylbenzoyl)-5-hydroxy-1-ethyl-3-methylpyrazole and 0.20 g (1.1 mmol) of p-Tos-Cl were dissolved in 20 ml of CH3CN. 0.26 g (1.8 mmol) of potassium carbonate was then added, and the mixture was stirred at room temperature for 12 h. The mixture was diluted with water and extracted with ethyl acetate. The extract was dried with MgSO4 and concentrated. This gave 4-(4-Trifluoromethyl-2-methylsulfonylbenzoyl)-l-ethyl-3-methyl-5-pyrazolyl tosylate as a wax.

Workup

  1. extractionextracted with ethyl acetate
  2. dry with materialThe extract was dried with MgSO4
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-1f30d75bea7c4a3a9887df804672753f
Source dataset
uspto-grants-2002_07
Patent number
US06420317B1

Reaction notes

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