Methyl isothiocyanate → 1-(2-Aminobenzoyl) 4-methylthiosemicarbazide

HRID 2229160Notes

Reaction equation

HRID 2229160 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH2:7])=[O:5].[CH3:12][N:13]=[C:14]=[S:15]>CN(C=O)C>[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][NH:7][C:14]([NH:13][CH3:12])=[S:15])=[O:5]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 94728Benzoic acid, 2-amino-, hydrazide

Product 1

HCID 178107641-(2-Aminobenzoyl) 4-methylthiosemicarbazide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2-aminobenzoic hydrazide (1.5 g) in DMF was added 0.7 g of methyl isothiocyanate and the mixture was stand for a day. The solvent was removed and chloroform was added to the residue to give 2.1 of 1-(2-aminobenzoyl) 4-methylthiosemicarbazide as a precipitate.

Workup

  1. customfor a day
  2. customThe solvent was removed
  3. additionchloroform was added to the residue

Sources & evidence

ORD record
ord-99869efab0564069b3594be42deab20d
Source dataset
uspto-grants-2002_07
Patent number
US06420367B1

Reaction notes

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