反应详情

温度

60 °C

To a solution of compound 3 (5.000 g, 17 mmol) in DMF (15 mL) was added K2CO3 (3.51 g, 26 mmol) and Boc-2-amino ethyl bromide (4.56 g, 20.35 mmol). The resulting mixture was stirred at 60° C. for three hours. The mixture was diluted with water and extracted with EtOAc (3×50 mL). The organic layers were combined, dried over Na2SO4, and concentrated. Purification with column chromatography (Hexanes/EtOAc 50:50) gave the product 4 (4.08 g, 55%) as white solid.

1. extractionextracted with EtOAc (3×50 mL)
2. dry with materialdried over Na2SO4
3. concentrationconcentrated
4. customPurification with column chromatography (Hexanes/EtOAc 50:50)