2,2-Diethoxyethylamine → HCID 178472155, compound

HRID 2229443Notes

Reaction equation

HRID 2229443 reaction equation
[NH:1]=[C:2]([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([NH:21][CH:22]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])(=[O:20])=[O:19])[CH:13]=2)[CH:9]=[CH:10][CH:11]=1)SC.[CH2:35]([O:37][CH:38]([O:41][CH2:42][CH3:43])[CH2:39][NH2:40])[CH3:36].ClCCl.CCOC(C)=O>C(O)CC>[CH2:35]([O:37][CH:38]([O:41][CH2:42][CH3:43])[CH2:39][NH:40][C:2]([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([NH:21][CH:22]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])(=[O:20])=[O:19])[CH:13]=2)[CH:9]=[CH:10][CH:11]=1)=[NH:1])[CH3:36]

Participants

5

Reactant 3

HCID 695242,2-DiethoxyethylamineHCID 21226138Dichloromethane ethylacetateHCID 178418706HCID 178418706, compound

Product 1

HCID 178472155HCID 178472155, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

1.25 g Ethyl 3-{[(3′-{[imino(methylsulfanyl)methyl]amino}[1,1′-biphenyl]-3-yl)-sulfonyl]amino}-3-phenyl-propanoate 14.1.2 were dissolved in 20 ml n-propanol and 0.32 g aminoacetaldehyde-diethylacetal were added dropwise to the boiling solution within 6 h. flash chromatography (dichloromethane/acetic acid ethyl ester4+1) yielded 1.1 g.

Workup

  1. customyielded 1.1 g

Sources & evidence

ORD record
ord-75cdd1ae67bd49c4adab0d2cf02c8b9d
Source dataset
uspto-grants-2002_07
Patent number
US06420396B1

Reaction notes

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