HRID2229443

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID69524

2,2-Diethoxyethanamine

C6H15NO2

HCID21226138

未命名化合物

结构：CCOC(=O)CC(NS(=O)(=O)c1cccc(-c2cccc(NC(=N)SC)c2)c1)c1ccccc1

HCID178418706

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CC(NS(=O)(=O)c1cccc(-c2cccc(NC(=N)NCC(OCC)OCC)c2)c1)c1ccccc1

HCID178472155

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1031

1-Propanol

C3H8O

PROCEDURE

实验过程

1.25 g Ethyl 3-{[(3′-{[imino(methylsulfanyl)methyl]amino}[1,1′-biphenyl]-3-yl)-sulfonyl]amino}-3-phenyl-propanoate 14.1.2 were dissolved in 20 ml n-propanol and 0.32 g aminoacetaldehyde-diethylacetal were added dropwise to the boiling solution within 6 h. flash chromatography (dichloromethane/acetic acid ethyl ester4+1) yielded 1.1 g.

WORKUP

后处理

customyielded 1.1 g

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-75cdd1ae67bd49c4adab0d2cf02c8b9d
来源数据集: uspto-grants-2002_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06420396B1
来源说明: uspto-grants-2002_07

反应 SMILES

[NH:1]=[C:2]([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([NH:21][CH:22]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])(=[O:20])=[O:19])[CH:13]=2)[CH:9]=[CH:10][CH:11]=1)SC.[CH2:35]([O:37][CH:38]([O:41][CH2:42][CH3:43])[CH2:39][NH2:40])[CH3:36].ClCCl.CCOC(C)=O>C(O)CC>[CH2:35]([O:37][CH:38]([O:41][CH2:42][CH3:43])[CH2:39][NH:40][C:2]([NH:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([S:18]([NH:21][CH:22]([C:29]3[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=3)[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])(=[O:20])=[O:19])[CH:13]=2)[CH:9]=[CH:10][CH:11]=1)=[NH:1])[CH3:36]