Hydrochloric Acid → HCID 70180063, compound

HRID 2229500Notes

Reaction equation

HRID 2229500 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[C@@H:5]([NH:18]C(OC(C)(C)C)=O)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][S:14]([CH3:17])(=[O:16])=[O:15])=[CH:9][CH:8]=1)[CH3:2].[ClH:27]>O1CCOCC1>[ClH:27].[CH2:1]([O:3][C:4](=[O:26])[C@@H:5]([NH2:18])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH:13][S:14]([CH3:17])(=[O:15])=[O:16])=[CH:11][CH:12]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54088829HCID 54088829, compound

Product 1

HCID 70180063HCID 70180063, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

(S)-Ethyl-2-tert-butyloxycarbonylamino-3-(4-methanesulfonylaminophenyl)propionate (3.00 g, 7.76 mmol) was dissolved in a solution of 4 N HCl in dioxane (10 mL). The bright orange solution was allowed to stir at room temperature overnight. The solvent was then evaporated and the residue azeotroped with toluene, furnishing the product as a bright peach solid (2.5 g, 100%).

Workup

  1. customThe solvent was then evaporated
  2. customthe residue azeotroped with toluene

Sources & evidence

ORD record
ord-79017bec33fb4799b343ab3e0e513a69
Source dataset
uspto-grants-2002_07
Patent number
US06420424B1

Reaction notes

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