Potassium Carbonate → 5169-81-3

HRID 2229834Notes

Reaction equation

HRID 2229834 reaction equation
[CH3:1][C:2]1[O:11][C:10](=[O:12])[C:9]2[C:8](=[O:13])[CH2:7][CH:6]([CH:14]([CH3:16])[CH3:15])[O:5][C:4]=2[CH:3]=1.C(=O)([O-])[O-].[K+].[K+]>CC(O)C>[OH:5][C:4]1[CH:3]=[C:2]([CH3:1])[O:11][C:10](=[O:12])[C:9]=1[C:8](=[O:13])[CH:7]=[CH:6][CH:14]([CH3:15])[CH3:16]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 10125188HCID 10125188, compound

Product 1

HCID 1362314175169-81-3Yield 75.6%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a mixture of 450 mg of 2, 3-dihydro-7-methyl-2-(1-methylethyl)-4H,5H-pyrano[4,3-b]pyran-4,5-dione and 40 ml of 2-propanol, 400 mg of potassium carbonate were added and stirred at room temperature for 12 hours. The reaction mixture was then concentrated, and methyl t-butyl ether and 3% hydrochloric acid were added thereto. The separated organic layer was washed with saturated brine once, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 340 mg of 4-hydroxy-6-methyl- 3-(4-methyl-2-pentenoyl)-2-pyrone.

Workup

  1. additionwere added
  2. concentrationThe reaction mixture was then concentrated
  3. additionmethyl t-butyl ether and 3% hydrochloric acid were added
  4. washThe separated organic layer was washed with saturated brine once
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-686067805f8945bc8cb1702492db6b28
Source dataset
uspto-grants-2002_07
Patent number
US06420569B1

Reaction notes

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