Hydrochloric Acid → HCID 18465469, compound

HRID 2230174Notes

Reaction equation

HRID 2230174 reaction equation
[O:1]=[C:2]1[N:6]([CH2:7][CH2:8][NH:9]C(=O)OC(C)(C)C)[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[N:3]1[CH:21]1[CH2:26][CH2:25][N:24]([C:27]2([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[CH2:23][CH2:22]1.[ClH:40]>CO>[ClH:40].[ClH:40].[NH2:9][CH2:8][CH2:7][N:6]1[C:5]2[CH:17]=[CH:18][CH:19]=[CH:20][C:4]=2[N:3]([CH:21]2[CH2:26][CH2:25][N:24]([C:27]3([C:34]4[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=4)[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]3)[CH2:23][CH2:22]2)[C:2]1=[O:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18465425HCID 18465425, compound

Product 1

HCID 18465469HCID 18465469, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of t-butyl N-(2-{2-oxo-3-[1-(1-phenylcycloheptyl)-4-piperidyl]-2,3-dihydro-1H-benzimidazol-1-yl}ethyl)carbamate (35 mg, 0.0657 mmol, this was prepared as Preparation 18) and HCl solution in MeOH (2 ml) was stirred at room temperature for 15 h. The reaction mixture was concentrated in vacuo to give 33.2 mg (100%) of white solid.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-f17cdd7fb8514f109a1d69855d55a91a
Source dataset
uspto-grants-2002_07
Patent number
US06423725B1

Reaction notes

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