Water → 4'-Tetrahydropyranyloxy-acetophenone

HRID 2230219Notes

Reaction equation

HRID 2230219 reaction equation
[CH3:1][C:2]([C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1)=[O:3].[O:11]1[CH:16]=[CH:15][CH2:14][CH2:13][CH2:12]1.O>C(Cl)Cl.C1(C)C=CC(S(O)(=O)=O)=CC=1>[O:11]1[CH2:16][CH2:15][CH2:14][CH2:13][CH:12]1[O:10][C:7]1[CH:8]=[CH:9][C:4]([C:2](=[O:3])[CH3:1])=[CH:5][CH:6]=1

Participants

6

Reactant 3

HCID 962WaterHCID 74694'-HydroxyacetophenoneHCID 80803,4-dihydro-2H-pyran2×

Product 1

HCID 113903814'-Tetrahydropyranyloxy-acetophenoneYield 62%

Reagents, catalysts & solvents 2

HCID 6101p-Toluenesulfonic acidCatalystHCID 6344DichloromethaneSolvent

Procedure

13.62 g (100 mmol) of 4-hydroxyacetophenone and 10.04 ml (110 mmol) of 3,4-dihydro-2H-pyran were suspended in 100 ml of anhydrous methylene chloride. At 0° C., 190 mg (1 mmol) of p-toluenesulfonic acid were added with stirring and the mixture was stirred at 0° C. for 3 hours. 10.04 ml (110 mmol) of 3,4-dihydro-2H-pyran were added again and the mixture was stirred at room temperature for a further 3 hours. The batch was poured into 150 ml of water, the phases were separated and the organic phase was extracted with saturated NaHCO3 solution, saturated NaCl solution and with water. The organic phase was dried over sodium sulfate, concentrated and, for purification, chromatographed on silica gel (70-200 μm) using methylene chloride as an eluent. 13.65 g (62%) of 10.1 were obtained.

Workup

  1. stirringthe mixture was stirred at 0° C. for 3 hours
  2. stirringthe mixture was stirred at room temperature for a further 3 hours
  3. customthe phases were separated
  4. extractionthe organic phase was extracted with saturated NaHCO3 solution, saturated NaCl solution and with water
  5. dry with materialThe organic phase was dried over sodium sulfate
  6. concentrationconcentrated and, for purification
  7. customchromatographed on silica gel (70-200 μm)

Sources & evidence

ORD record
ord-abf355f6d1004689976414ab3f0c23dd
Source dataset
uspto-grants-2002_07
Patent number
US06423712B1

Reaction notes

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