Ammonium Hydroxide → HCID 70179406, compound

HRID 2230269Notes

Reaction equation

HRID 2230269 reaction equation
[CH:1]1([CH2:13][C:14]#N)[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH:6]=[CH:5][CH:4]=[C:3]3[CH2:2]1.[OH-].[NH4+:17]>CO.[Ni]>[CH:1]1([CH:13]([NH2:17])[CH3:14])[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH:6]=[CH:5][CH:4]=[C:3]3[CH2:2]1

Participants

5

Reactant 2

HCID 14923Ammonium HydroxideHCID 10821610HCID 10821610, compound

Product 1

HCID 70179406HCID 70179406, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

The nitrile obtained in Step B (900 mg, 4.66.10−3 mol), diluted with methanol (30 ml), is hydrogenated with vigorous stirring at ambient temperature in the presence of ammonium hydroxide (2 ml) and Raney nickel. After 23 hours, the starting material has disappeared. After filtering over Celite, then rinsing and evaporating off the solvent under reduced pressure, the title amine is obtained in the form of an oil, which is used without being purified.

Workup

  1. filtrationAfter filtering over Celite
  2. washrinsing
  3. customevaporating off the solvent under reduced pressure

Sources & evidence

ORD record
ord-70e19e6310744cc0896db9a87ecf0ef3
Source dataset
uspto-grants-2002_07
Patent number
US06423870B1

Reaction notes

Loading…