Dimethyl Sulfate → HCID 15859298, compound

HRID 2230271Notes

Reaction equation

HRID 2230271 reaction equation
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:12]2[C:15]3[C:4]=1[CH2:5][CH2:6][CH:7]([CH2:16][NH:17][C:18]([CH:20]1[CH2:22][CH2:21]1)=[O:19])[C:8]=3[CH:9]=[CH:10][CH:11]=2.[H-].[Na+].S(OC)(O[CH3:29])(=O)=O>>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:12]2[C:15]3[C:4]=1[CH2:5][CH2:6][CH:7]([CH2:16][N:17]([CH3:29])[C:18]([CH:20]1[CH2:22][CH2:21]1)=[O:19])[C:8]=3[CH:9]=[CH:10][CH:11]=2

Participants

4

Reactant 3

HCID 6497Dimethyl SulfateHCID 24758Sodium hydrideHCID 9817636HCID 9817636, compound

Product 1

HCID 15859298HCID 15859298, compound

Procedure

The compound obtained in Example 3 is reacted in the presence of NaH (1.5 eq) and dimethyl sulphate (1.2 eq). The reaction is monitored using TLC. When all the starting material has disappeared, the reaction mixture is hydrolysed and then extracted. After evaporating off the solvents, the title product is isolated by flash chromatography.

Workup

  1. extractionextracted
  2. customAfter evaporating off the solvents

Sources & evidence

ORD record
ord-973d7bebbda442fdae8734a466655bab
Source dataset
uspto-grants-2002_07
Patent number
US06423870B1

Reaction notes

Loading…