Hydrochloric Acid → HCID 18466109, compound

HRID 2230272Notes

Reaction equation

HRID 2230272 reaction equation
C[O:2][C:3]1[CH:11]=[CH:10][C:9]2[N:8]([CH3:12])[CH:7]=[C:6]3[CH:13]([CH2:16][N:17]([CH3:21])[C:18](=[O:20])[CH3:19])[CH2:14][CH2:15][C:4]=1[C:5]=23.[Cl-].[Al+3].[Cl-].[Cl-].C1C=CC(CS)=CC=1.Cl>ClCCl>[OH:2][C:3]1[CH:11]=[CH:10][C:9]2[N:8]([CH3:12])[CH:7]=[C:6]3[CH:13]([CH2:16][N:17]([CH3:21])[C:18](=[O:20])[CH3:19])[CH2:14][CH2:15][C:4]=1[C:5]=23

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7509Benzyl mercaptanHCID 6451240Aluminum(III) ChlorideHCID 18466228HCID 18466228, compound

Product 1

HCID 18466109HCID 18466109, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The compound of Example 27, dissolved in dichloromethane, is added dropwise at 0° C. to a suspension of aluminium chloride and benzylthiol. The reaction is monitored by TLC. When the reaction has ended, the reaction mixture is poured onto ice and then acidified using 1N HCl. Customary extraction is carried out and the title compound is isolated by chromatography.

Workup

  1. additionthe reaction mixture is poured onto ice
  2. extractionCustomary extraction

Sources & evidence

ORD record
ord-5cb81d3c76644eafad51463530e80a4b
Source dataset
uspto-grants-2002_07
Patent number
US06423870B1

Reaction notes

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