Oxalyl chloride → 2-Methoxy-5-(1H-triazol-1-ylmethyl)benzoyl Chloride

HRID 2230615Notes

Reaction equation

HRID 2230615 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[CH:17]=[CH:16][N:15]=[N:14]2)=[CH:8][C:4]=1[C:5](O)=[O:6].C(Cl)(=O)C([Cl:21])=O>CN(C)C=O.ClCCl>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]([CH2:12][N:13]2[CH:17]=[CH:16][N:15]=[N:14]2)=[CH:8][C:4]=1[C:5]([Cl:21])=[O:6]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 184650502-methoxy-5-(1H-triazol-1-ylmethyl)benzoic acid

Product 1

HCID 184645252-Methoxy-5-(1H-triazol-1-ylmethyl)benzoyl Chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

Combine 2-methoxy-5-(1H-triazol-1-ylmethyl)benzoic acid (0.22 g, 0.94 mmol) and dichloromethane (50 mL). Add dropwise oxalyl chloride (0.14 mL, 1.6 mmol) followed by dimethylformamide (5 drops). After 4 hours, evaporate in vacuo and dry to give the title compound.

Workup

  1. customevaporate in vacuo
  2. customdry

Sources & evidence

ORD record
ord-577f56e0b4ce4b5dbfa026671e73d285
Source dataset
uspto-grants-2002_07
Patent number
US06423704B1

Reaction notes

Loading…