Hydrogen iodide → HCID 18464587, compound

HRID 2230706Notes

Reaction equation

HRID 2230706 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([C:15]2[N:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:18]3[CH:25]=[CH:26][CH:27]=[CH:28][C:17]=3[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[IH:29]>C(O)C>[IH:29].[IH:29].[N:11]1([C:15]2[N:19]([CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[C:18]3[CH:25]=[CH:26][CH:27]=[CH:28][C:17]=3[N:16]=2)[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 24841Hydrogen iodideHCID 212238131-t-butoxycarbonyl-4-(1-pentyl-1H-benzimidazol-2-yl)[1,4]diazepane

Product 1

HCID 18464587HCID 18464587, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrolyze 4-(1-pentyl-1H-benzoimidazol-2-yl)-[1,4]diazepane-1-carboxylic acid tert-butyl ester (0.70 g, 1.81 mmol) by refluxing an ethanol solution of the compound with hydroiodic acid (57%, 5 mL) as described in Example 111 to provide 2-[1,4]diazepan-1-yl-1-pentyl-1H-benzoimidazole dihydroiodide (0.85 g).

Sources & evidence

ORD record
ord-8d73663ab474467381963149aede2850
Source dataset
uspto-grants-2002_07
Patent number
US06423704B1

Reaction notes

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