反应详情

A mixture of 2-bromo-3′-nitroacetophenone (3.66 g) and 3-thiocarbamoylpyridine (2.07 g) in ethanol (40 ml) was refluxed for 1 hour. The reaction mixture was poured into a mixture of ethyl acetate and an aqueous sodium bicarbonate solution. The organic phase was washed with brine, dried over magnesium sulfate and concentrated. The resultant solid was collected and washed with isopropyl ether to give 4-(3-nitrophenyl)-2-(pyridin-3-yl)thiazole (2.91 g).

1. temperaturewas refluxed for 1 hour
2. washThe organic phase was washed with brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe resultant solid was collected
6. washwashed with isopropyl ether