反应详情

A mixture of 3-nitrobenzoyl chloride (3.71 g), anisole (2.0 ml) and aluminum chloride (2.67 g) in dichloromethane (50 ml) was refluxed for 1 hour. The reaction mixture was poured into a mixture of ethyl acetate and water. The organic phase was washed with brine, dried over magnesium sulfate and concentrated. The resultant solid was collected and washed with ethyl acetate to give 1-(3-nitrobenzoyl)-4-methoxybenzene (955 mg).

1. temperaturewas refluxed for 1 hour
2. washThe organic phase was washed with brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated
5. customThe resultant solid was collected
6. washwashed with ethyl acetate