反应详情

To a mixture of 9-chloro-2-(4-nitrophenyl)-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one in ethanol and water is added iron powder with stirring at room temperature. To the mixture is added dropwise concentrated hydrochloric acid with stirring and heating up to 60° C. on a water bath. The resulting mixture is further stirred under heating at the same temperature and filtered, then the filtrate is concentrated. After the residue is made alkaline by adding an aqueous solution of sodium hydroxide, the mixture is extracted with chloroform. The extract is washed with water and dried over magnesium sulfate anhydride. The chloroform is distilled off to give 2-(4-aminophenyl)-9-chloro-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one.

1. stirringwith stirring
2. temperatureheating up to 60° C. on a water bath
3. stirringThe resulting mixture is further stirred
4. temperatureunder heating at the same temperature
5. filtrationfiltered
6. concentrationthe filtrate is concentrated
7. additionby adding an aqueous solution of sodium hydroxide
8. extractionthe mixture is extracted with chloroform
9. washThe extract is washed with water
10. dry with materialdried over magnesium sulfate anhydride
11. distillationThe chloroform is distilled off