Hydrochloric Acid → HCID 21286418, compound

HRID 2231222Notes

Reaction equation

HRID 2231222 reaction equation
[Al].[Li].[O:3]1[CH:7]=[CH:6][C:5]2[CH:8]=[CH:9][CH:10]=[C:11]([N:12]3[CH2:17][CH2:16][N:15]([C:18]([CH:20]4[CH2:22][CH2:21]4)=O)[CH2:14][CH2:13]3)[C:4]1=2.[OH-].[Na+].[ClH:25]>O1CCCC1.O>[ClH:25].[O:3]1[CH:7]=[CH:6][C:5]2[CH:8]=[CH:9][CH:10]=[C:11]([N:12]3[CH2:13][CH2:14][N:15]([CH2:18][CH:20]4[CH2:21][CH2:22]4)[CH2:16][CH2:17]3)[C:4]1=2

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14960336HCID 14960336, compoundHCID 16211445Aluminum;lithium

Product 1

HCID 21286418HCID 21286418, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

0.28 g Of lithium aluminum hydide were added in small portions to a solution of 5.8 mmol (1.56 g) of 1-(benzo[b]furan-7-yl)-4-(cyclopropylcarbonyl)piperazine in 30 ml of dry tetrahydrofuran. The mixture was stirred until the formation of gas stopped. After adding of 5 ml of water and 50 ml of 2N sodium hydroxide the reaction mixture was extracted and the organic layers were evaporated. Chromatographic purification on silica gel resulted in 1.0 g of a viscous substance, which was converted into the title compound by treatment with 1 equivalent of HCl. in ethyl acetate.

Workup

  1. extractionwas extracted
  2. customthe organic layers were evaporated
  3. customChromatographic purification on silica gel
  4. customresulted in 1.0 g of a viscous substance, which

Sources & evidence

ORD record
ord-bc550a0e0f0a45eaba3d8a0a01e8c0d9
Source dataset
uspto-grants-1988_11
Patent number
US04782061

Reaction notes

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