Selenium Dioxide → 3H-Imidazo[4,5-c]pyridine-2-carboxaldehyde, 3-methyl-

HRID 2231260Notes

Reaction equation

HRID 2231260 reaction equation
[CH3:1][C:2]1[N:10]([CH3:11])[C:5]2[CH:6]=[N:7][CH:8]=[CH:9][C:4]=2[N:3]=1.[Se](=O)=[O:13]>O1CCOCC1>[CH3:11][N:10]1[C:5]2[CH:6]=[N:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[CH:1]=[O:13]

Participants

4

Reactant 2

HCID 24007Selenium DioxideHCID 122393252,3-Dimethyl-3H-imidazo[4,5-c]pyridine

Product 1

HCID 122393393H-Imidazo[4,5-c]pyridine-2-carboxaldehyde, 3-methyl-Yield 52.2%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Employing the procedure of Example 10B and starting with 774 mg of 2,3-dimethyl-3H-imidazo[4,5-c]pyridine (Preparation J2) and 584 mg of selenium dioxide in 30 ml of dioxane, there was obtained 442 mg of the desired product.

Sources & evidence

ORD record
ord-26d3138f592c4ebc824fbc6aaa24cc3a
Source dataset
uspto-grants-1988_11
Patent number
US04782050

Reaction notes

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