Selenium Dioxide → 1-(Fluoromethyl)-1H-benzimidazole-2-carbaldehyde

HRID 2231261Notes

Reaction equation

HRID 2231261 reaction equation
[F:1][CH2:2][N:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[C:4]1[CH3:12].[Se](=O)=[O:14]>O1CCOCC1>[F:1][CH2:2][N:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[N:5]=[C:4]1[CH:12]=[O:14]

Participants

4

Reactant 2

HCID 24007Selenium DioxideHCID 212862911-(Fluoromethyl)-2-methyl-1H-benzimidazole

Product 1

HCID 150720551-(Fluoromethyl)-1H-benzimidazole-2-carbaldehydeYield 82.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using the procedure of Example 10B and starting with 2.87 g of 1-fluoromethyl-2-methylbenzimidazole and 1.94 g of selenium dioxide in 50 ml of dioxane, 2.58 g of the desired product was isolated.

Sources & evidence

ORD record
ord-add036958017437f95a1ce9ed0077260
Source dataset
uspto-grants-1988_11
Patent number
US04782050

Reaction notes

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