Hydrochloric Acid → 2-(2-Aminothiazol-4-yl)-2-butenoic acid

HRID 2231369Notes

Reaction equation

HRID 2231369 reaction equation
C([NH:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[CH:16][CH3:17])[C:11]([O:13]CC)=[O:12])[N:9]=1)(=O)C.[OH-].[K+].Cl>O>[NH2:4][C:5]1[S:6][CH:7]=[C:8]([C:10](=[CH:16][CH3:17])[C:11]([OH:13])=[O:12])[N:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 54352037Ethyl 2-(2-acetamidothiazol-4-yl)-2-butenoate

Product 1

HCID 536703542-(2-Aminothiazol-4-yl)-2-butenoic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8.4 parts by weight and ethyl 2-(2-acetamidothiazol-4-yl)-2-butenoate are added to a solution, warmed to 90° C., of 18.8 parts by weight of potassium hydroxide in 168 parts by volume of water. The solution is stirred for 45 minutes at the same temperature, cooled and brought to pH 3.6 with concentrated hydrochloric acid, with cooling.

Workup

  1. temperaturecooled
  2. temperaturewith cooling

Sources & evidence

ORD record
ord-3e6f2d7ca19a487f8f480666fa2fccb9
Source dataset
uspto-grants-1988_11
Patent number
US04782162

Reaction notes

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