反应详情

A mixture comprising 14.0 g of 2-t-butyl-4-n-propyl-5-chloro-3(2H)pyridazinone, 44 g of 3-hydroxypropylamine and 14.8 g of anhydrous potassium carbonate, was stirred at a temperature of from 145° to 155° C. for 12.5 hours. The reaction solution was returned to room temperature, and about 200 ml of cold water was added. The mixture was stirred. The precipitated white crystals were collected by filtration, and dried to obtain 12.1 g of the above identified compound having a melting point of from 167° to 169° C.

1. customwas returned to room temperature
2. stirringThe mixture was stirred
3. filtrationThe precipitated white crystals were collected by filtration
4. customdried
5. customto obtain 12.1 g of the
6. customof from 167° to 169° C.