Potassium Carbonate → HCID 5375494, compound

HRID 2231836Notes

Reaction equation

HRID 2231836 reaction equation
C(=O)([O-])[O-].[K+].[K+].[C:7]([CH2:9]P(=O)(OCC)OCC)#[N:8].[Cl:18][C:19]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:20]=1[CH:21]=O>O.O1CCCC1>[Cl:18][C:19]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:20]=1/[CH:21]=[CH:9]/[C:7]#[N:8]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 134042,4-DichlorobenzaldehydeHCID 75676Diethyl (cyanomethyl)phosphonate

Product 1

HCID 5375494HCID 5375494, compoundYield 74%

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 8 g of potassium carbonate in 10 cm3 of water, 6 g (0.034 mol) of diethyl cyanomethylphosphonate are added followed by 5 g of 2,4-dichlorobenzaldehyde solubilized in 10 cm3 of anhydrous tetrahydrofuran. The mixture is left stirred for 10 minutes at room temperature and 20 cm3 of water are added. The precipitate formed is washed with water to neutrality (8 times with 20 cm3 of water), and then washed with an ether/hexane mixture. 3.7 g (74%) of trans-2,4-dichlorocinnamonitrile are obtained in the form of white crystals, m.p. 156° C.

Workup

  1. waitThe mixture is left
  2. customThe precipitate formed
  3. washis washed with water to neutrality (8 times with 20 cm3 of water)
  4. washwashed with an ether/hexane mixture

Sources & evidence

ORD record
ord-793d12fd459d4e75ad1f92f82dd86199
Source dataset
uspto-grants-1988_11
Patent number
US04785007

Reaction notes

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