Ammonium Chloride → 2-[(5-Methyl-1H-pyrrol-2-yl)methyl]-1H-isoindole-1,3(2H)-dione

HRID 2231866Notes

Reaction equation

HRID 2231866 reaction equation
[C:1]1(=[O:19])[N:5]([CH2:6][C:7](=O)[CH2:8][CH2:9][C:10](=O)[CH3:11])[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]12.C([O-])(=O)C.[NH4+:24].[Cl-].[NH4+]>C(O)(=O)C>[C:1]1(=[O:19])[N:5]([CH2:6][C:7]2[NH:24][C:10]([CH3:11])=[CH:9][CH:8]=2)[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]12

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 517165Ammonium AcetateHCID 123484512-(2,5-Dioxohexyl)-1H-isoindole-1,3(2H)-dione

Product 1

HCID 133647922-[(5-Methyl-1H-pyrrol-2-yl)methyl]-1H-isoindole-1,3(2H)-dione

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

36.3 g (0.14 mol) of 6-phthalimido-2,5-hexanedione, 54 g (0.7 mol) of ammonium acetate and 1 g of ammonium chloride are stirred in 700 ml of acetic acid at 80° C. for 1 hour and the mixture is worked up as in Example 1.

Sources & evidence

ORD record
ord-1b793260a5364b4291f77f2b4e3eb9a3
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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