Glycine tert-butyl ester → HCID 13534393, compound

HRID 2231882Notes

Reaction equation

HRID 2231882 reaction equation
[C:1]1(=[O:19])[N:5]([CH2:6][C:7](=O)[CH2:8][CH2:9][C:10](=O)[CH3:11])[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]12.[C:20]([O:24][C:25](=[O:28])[CH2:26][NH2:27])([CH3:23])([CH3:22])[CH3:21]>O1CCCC1>[C:20]([O:24][C:25]([CH2:26][N:27]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]1[CH2:6][N:5]1[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]2[C:1]1=[O:19])=[O:28])([CH3:23])([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 151417Glycine tert-butyl esterHCID 123484512-(2,5-Dioxohexyl)-1H-isoindole-1,3(2H)-dione

Product 1

HCID 13534393HCID 13534393, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

13.0 g (0.05 mol) of 6-phthalimido-2,5-hexanedione and 6.6 g (0.05 mol) of glycine tert.-butyl ester are stirred in 250 ml of tetrahydrofuran at 80° C. for 20 hours and the mixture is worked up as in Example 27.

Sources & evidence

ORD record
ord-dfaa8930f03a490fb32b951886f301b4
Source dataset
uspto-grants-1988_11
Patent number
US04785010

Reaction notes

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