Triethylamine → HCID 86742533, compound

HRID 2231976Notes

Reaction equation

HRID 2231976 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([Cl:10])[C:5]([Cl:11])=[N:4][C:3]=1[Cl:12].NCCNC(=O)[CH:18]([C:20]1[CH:25]=[C:24]([C:26]([CH3:29])([CH3:28])[CH3:27])[C:23]([OH:30])=[C:22]([C:31]([CH3:34])([CH3:33])[CH3:32])[CH:21]=1)[CH3:19].C([N:38](CC)CC)C.C[N:44]1[CH2:48][CH2:47]C[C:45]1=[O:49]>>[C:31]([C:22]1[CH:21]=[C:20]([CH2:18][CH2:19][C:45]([NH:44][CH2:48][CH2:47][NH:38][C:2]2[C:7]([C:8]#[N:9])=[C:6]([Cl:10])[C:5]([Cl:11])=[N:4][C:3]=2[Cl:12])=[O:49])[CH:25]=[C:24]([C:26]([CH3:29])([CH3:27])[CH3:28])[C:23]=1[OH:30])([CH3:34])([CH3:33])[CH3:32]

Participants

5

Reactant 4

HCID 8471TriethylamineHCID 13387N-methyl-2-pyrrolidoneHCID 6180362,3,5,6-TetrachloroisonicotinonitrileHCID 22104623HCID 22104623, compound

Product 1

HCID 86742533HCID 86742533, compound

Procedure

24.2 g of tetrachloroisonicotinonitrile and 32 g of 3,5-di-tert-butyl-4-hydroxyphenylpropionic acid 2-aminoethylamide are reacted with 11 g of triethylamine in 0.2 l of N-methylpyrrolidone in the manner described in Example 2. The toluene extract is evaporated down, and the residue is recrystallized from a 4:1 mixture of cyclohexane and toluene with the addition of active carbon. The product has a melting point of 150°-160° C.

Workup

  1. extractionThe toluene extract
  2. customis evaporated down
  3. customthe residue is recrystallized from a 4:1 mixture of cyclohexane and toluene with the addition of active carbon

Sources & evidence

ORD record
ord-3d29ea5492ee4c358d0c8f921a63ebb7
Source dataset
uspto-grants-1988_11
Patent number
US04785107

Reaction notes

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