Hydrogen Peroxide → HCID 24806201, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([Cl:12])[N:11]=1)[C:5]([O:7][CH3:8])=[O:6].[OH:13]O>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]=[C:10]([Cl:12])[N+:11]=1[O-:13])[C:5]([O:7][CH3:8])=[O:6]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 90 °C
Procedure
A stirred mixture of 15.3 g (0.073 mole) of methyl 2,6-dichloroisonicotinate in 180 ml of trifluoroacetic acid was heated at 90° C. During a six hour period 34 ml of 30% hydrogen peroxide was added to the hot reaction mixture in four to five ml aliquots. After complete addition the reaction mixture was stirred at 90° C. for two hours. The solvent was distilled from the mixture under reduced pressure to leave a solid. The solid was triturated with water, and the mixture was then filtered. The filter cake was recrystallized from acetone to yield 8.75 g of methyl 2,6-dichloroisonicotinate N-oxide.
Workup
- additionAfter complete addition the reaction mixture
- distillationThe solvent was distilled from the mixture under reduced pressure
- customto leave a solid
- customThe solid was triturated with water
- filtrationthe mixture was then filtered
- customThe filter cake was recrystallized from acetone
Sources & evidence
- ORD record
- ord-4cd0a104f5764cd89274059e4382e7fb
- Source dataset
- uspto-grants-1988_11
- Patent number
- US04787931
Reaction notes
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